ANDROGEN STIMULATED PUBERTAL GROWTH--ROLE OF GH AND IGF1

雄激素刺激青春期生长——GH 和 IGF1 的作用

• 批准号: 3785353
• 负责人: BRUCE S. KEENAN
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3785353
• 关键词: adolescence (12-20); blood chemistry; dihydrotestosterone; endocrine disorder chemotherapy; growth /development; hormone regulation /control mechanism; hormone therapy; human puberty; human subject; human therapy evaluation; hypogonadism; insulinlike growth factor; male; somatotropin; testosterone

Analyzes the androgenic and estrogenic effects of testosterone (T) in stimulating growth and the production of growth hormone (GH) and IGF1 at puberty. Boys with delayed puberty will be treated either with T or dihydrotestosterone (DHT). Those effects seen with T treatment but not with DHT are attributable to estradiol, whereas the effects of DHT are considered purely androgenic. Parameters to be followed include height velocity, bone age, spontaneous and stimulated plasma GH, and IGF1.

分析睾酮（T）的雄激素和雌激素作用， 刺激生长和生长激素（GH）和IGF1的产生， 青春期 青春期延迟的男孩将接受T或 双氢睾酮（DHT）。 T治疗时观察到的效应， 与双氢睾酮是由于雌二醇，而双氢睾酮的影响， 被认为是纯雄性的 要遵循的参数包括高度 速度、骨龄、自发和刺激的血浆GH和IGF 1。