NEUROTRANSMITTER REGULATION OF GROWTH HORMONE SECRETION

生长激素分泌的神经递质调节

• 批准号: 3785315
• 负责人: BRUCE S. KEENAN
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3785315
• 关键词: 5 hydroxytryptophan; apomorphine; child (0-11); child physical development; clonidine; dihydroxyphenylalanine; drug administration routes; endocrine disorder diagnosis; endocrine pharmacology; hormone regulation /control mechanism; human subject; insulin; neuroendocrine system; neurotransmitters; postnatal growth disorder; secretion; somatotropin

Tests the hypothesis that some children with short stature have defects in their ability to regulate growth hormone secretion that is not detected by the standard provocative test of growth hormone secretion. Hypothesis will be tested by studying several categories of short children by means of a 24 hr pump for growth hormone secretion, insulin/L dopa test, apomorphine test, clonidine test, and 5-hydroxytryptophan test.

测试了一些身材矮小的孩子有缺陷的假设 它们调节生长激素分泌的能力， 通过生长激素分泌的标准激发试验检测。 假设将通过研究几类短期的 儿童通过24小时泵进行生长激素分泌，胰岛素/L 多巴试验、阿扑吗啡试验、可乐定试验和5-羟色氨酸 test.