EFFECT OF THERAPY IN ADRENAL STEROID PRODUCTION IN ADRENAL HYPERPLASIA

肾上腺皮质增生症治疗对肾上腺类固醇产生的影响

• 批准号: 3884384
• 负责人: BRUCE S. KEENAN
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3884384
• 关键词: Cushing's syndrome; adrenal hyperplasia; androgens; androstenedione; blood chemistry; cortisol; genetic disorder diagnosis; human subject; human therapy evaluation; infant human (0-1 year); middle childhood (6-11); neoplasm /cancer; pediatric pharmacology; renin

Plasma androstenedione (A) and plasma renin activity are measured to monitor treatment of patients with CAH. Plasma cortisol, adrenal androgens (A, testosterone, dehydroepiandrosterone) are measured; blood is gathered at 6-12h intervals for 1-3 days in infants and by constant withdrawal pump for 24h in older children with CAH, Cushing's syndrome, and virilizing tumors. ACTH test is performed to detect cryptic forms or carriers of CAH.

测量血浆雄烯二酮（A）和血浆肾素活性， 监测CAH患者的治疗。 血浆皮质醇，肾上腺 测量雄激素（A，睾酮，脱氢表雄酮）; 婴儿每隔6- 12小时采集1-3天， 在患有CAH、库欣综合征、 和男性化肿瘤 促肾上腺皮质激素测试进行检测神秘的形式或 CAH携带者