NEUROTRANSMITTER REGULATION OF GROWTH HORMONE SECRETION

生长激素分泌的神经递质调节

• 批准号: 3849048
• 负责人: BRUCE S. KEENAN
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3849048
• 关键词: 5 hydroxytryptophan; apomorphine; child (0-11); child physical development; clonidine; dihydroxyphenylalanine; drug administration routes; endocrine disorder diagnosis; hormone regulation /control mechanism; human subject; insulin; neurotransmitters; postnatal growth disorder; secretion; somatotropin

Tests the hypothesis that some children with short stature have defects in their ability to regulate growth hormone secretion that is not detected by the standard provocative test of growth hormone secretion. Hypothesis will be tested by studying several categories of short children by means of a 24 hr pump for growth hormone secretion, insulin/L dopa test, apomorphine test, clonidine test, and 5-hydroxytryptophan test.

检验一些身材矮小的儿童存在以下缺陷的假设 他们调节生长激素分泌的能力是无法检测到的 生长激素分泌的标准激发试验。 假设将 通过使用 24 种方法研究几类矮个子儿童来进行测试 用于生长激素分泌的小时泵、胰岛素/左旋多巴测试、阿扑吗啡 试验、可乐定试验和5-羟色氨酸试验。