EXPRESSION OF IL-4 RECEPTORS ON HUMAN TUMORS

IL-4 受体在人类肿瘤上的表达

• 批准号: 3792452
• 负责人: R PURI
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3792452
• 关键词: breast neoplasms; cytokine receptors; human tissue; interleukin 4; kidney neoplasms; melanoma; neoplasm /cancer immunology; ovary neoplasms; receptor expression

In this project, we are studying the expression of IL-4R and the role of IL-4 on solid human tumors. We have observed that human tumors of different histology also express IL-4R. Human breast carcinoma, ovarian carcinoma, melanoma and renal tumor lines, as well as fresh tumors obtained from the NCI, express high affinity IL-4R. The characteristics of these receptors appear to be similar to that reported on hematopoietic cells such as T cells, B cells, mast cells and macrophages. Human tumors also express a single species of mRNA of IL-4R. We are currently investigating the function of IL-4 on tumor cells. Our preliminary data indicate that IL-4 is directly growth inhibitory to some IL-4R positive tumor lines as tested by MTT assay. Furthermore, IL-4 appear to upregulate HLA-DR antigen on some tumor cells.

本研究旨在探讨IL-4 R在胃癌细胞中的表达以及IL-4在胃癌细胞中的作用。 IL-4对人实体肿瘤的作用 我们已经观察到， 不同组织学也表达IL-4 R。 人乳腺癌，卵巢 癌、黑色素瘤和肾肿瘤系，以及新鲜肿瘤 从NCI获得，表达高亲和力IL-4 R。 特点 这些受体似乎是类似的造血 细胞如T细胞、B细胞、肥大细胞和巨噬细胞。 人类肿瘤 也表达单一种类的IL-4 R mRNA。我们目前正在 探讨IL-4对肿瘤细胞的作用。 我们的初步数据 表明IL-4对某些IL-4 R阳性细胞具有直接生长抑制作用 MTT法检测肿瘤细胞的增殖。 此外，IL-4似乎 上调某些肿瘤细胞上的HLA-DR抗原。