INTERLEUKIN-4 RECEPTORS ON TUMOR INFILTRATING LYMPHOCYTES

肿瘤浸润淋巴细胞上的 INTERLEUKIN-4 受体

• 批准号: 3811185
• 负责人: R PURI
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3811185
• 关键词: antireceptor antibody; cytokine receptors; cytotoxic T lymphocyte; interleukin 2; interleukin 4; laboratory mouse; lymphocyte; neoplasm /cancer immunology; nucleic acid probes; protein biosynthesis; receptor expression

We have studied receptors for IL-4 on murine TIL and their regulation by cytokines. IL-2 upregulates IL-4 receptors on murine TIL in a dose dependen manner and its regulation is dependent on new receptor protein synthesis. The manuscript generated from this work has been accepted for publication in the Journal Immunology and due to be published in the next few weeks. This study was performed in collaboration with Drs. Jay Siegel and David Finbloom. This project is still active and currently I am studying IL-4 receptors at the molecular level by utilizing IL-4 receptor DNA probe and anti-IL-4 receptor antibody.

我们已经研究了小鼠TIL上IL-4的受体及其调节 细胞因子。IL-2上调小鼠TIL表面IL-4受体的作用 这种方式及其调控依赖于新的受体蛋白的合成。 从这部作品中产生的手稿已被接受出版 发表在《免疫学》杂志上，并将于未来几周发表。 这项研究是与Jay Siegel博士和David博士合作进行的 芬布卢姆。这个项目仍在进行中，目前我正在研究IL-4 利用IL-4受体DNA探针在分子水平上检测受体 抗IL-4受体抗体。