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CHARACTERIZATION OF TUMORS AND TIL FROM TUMORS INDUCED BY HHV-6

CHARACTERIZATION OF TUMORS AND TIL FROM TUMORS INDUCED BY HHV-6
HHV-6 诱导的肿瘤和 TIL 的特征
批准号：
3804729
负责人：
R PURI
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3804729
关键词：
cell mediated lymphocytolysis test cellular immunity cytotoxic T lymphocyte host neoplasm interaction human herpesvirus 6 laboratory mouse metastasis neoplasm /cancer immunology neoplasm /cancer immunotherapy oncogenic virus tissue /cell culture transfection transforming virus tumor antigens viral carcinogenesis virus related neoplasm /cancer

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中文摘要
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英文摘要
We have published results which indicated that tumors induced by HHV-6 DNA are tumorigenic in immunocompetent NIH-Swiss mice and tumor specific TIL can be generated from these tumors. The metastatic potential of NIH Swiss derived tumor is currently being studied. Since NIH Swiss mice are outbred mice, we are also currently pursuing our research to generate tumors by transfecting HHV-6 DNA into Balb/C or C57BL/6 mice-derived cells. Generation of tumors and TILs from inbred mice will be necessary before attempts are made to identify tumor associated antigens in vivo and in vitro. This project is still active.
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