CHARACTERIZATION OF TUMORS AND TIL FROM TUMORS INDUCED BY HHV-6

HHV-6 诱导的肿瘤和 TIL 的特征

• 批准号: 3804729
• 负责人: R PURI
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3804729
• 关键词: cell mediated lymphocytolysis test; cellular immunity; cytotoxic T lymphocyte; host neoplasm interaction; human herpesvirus 6; laboratory mouse; metastasis; neoplasm /cancer immunology; neoplasm /cancer immunotherapy; oncogenic virus; tissue /cell culture; transfection; transforming virus; tumor antigens; viral carcinogenesis; virus related neoplasm /cancer

We have published results which indicated that tumors induced by HHV-6 DNA are tumorigenic in immunocompetent NIH-Swiss mice and tumor specific TIL can be generated from these tumors. The metastatic potential of NIH Swiss derived tumor is currently being studied. Since NIH Swiss mice are outbred mice, we are also currently pursuing our research to generate tumors by transfecting HHV-6 DNA into Balb/C or C57BL/6 mice-derived cells. Generation of tumors and TILs from inbred mice will be necessary before attempts are made to identify tumor associated antigens in vivo and in vitro. This project is still active.

我们已经发表的结果表明，HHV-6 DNA诱导肿瘤