EXPRESSION OF IL-4 RECEPTORS ON HUMAN TUMORS

IL-4 受体在人类肿瘤上的表达

• 批准号: 3804731
• 负责人: R PURI
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3804731
• 关键词: MHC class II antigen; cellular immunity; cytokine receptors; growth inhibitors; human tissue; immunoregulation; interleukin 4; neoplastic cell; protein structure function; receptor expression

In this project, we are studying the expression of IL-4R and the role of IL-4 on solid human tumors. We have observed that human tumors of different histology also express IL-4R. Human breast carcinoma, ovarian carcinoma, melanoma and renal tumor lines, as well as fresh tumors obtained from the NCI, express high affinity IL-4R. The characteristics of these receptors appear to be similar to that reported on hematopoetic cells such as T cells, B cells, mast cells and macrophages. Human tumors also express a single species of IL-4R mRNA. We are currently investigating the function of IL-4 on tumor cells. Our preliminary data indicate that IL-4 is directly growth inhibitory to some IL-4R positive tumor lines as tested by MTT assay. Furthermore, IL-4 appear to upregulate HLA-DR antigen on some tumor cells. Experiments are underway which will examine the regulation of IL-4R on tumor cells. This project is currently active.

在本项目中，我们正在研究IL-4R的表达及其作用