PNEUMOCYSTIS CARINII BY INDUCED SPUTUM IN IMMUNOSUPPRESSED CHILDREN

免疫抑制儿童中诱发痰引起的卡氏肺囊虫

• 批准号: 3837915
• 负责人: F P OGNIBENE
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3837915
• 关键词: Pneumocystis carinii; Pneumocystis pneumonia; child (0-11); diagnosis design /evaluation; diagnosis procedure safety; human subject; longitudinal human study; opportunistic infections; pediatric AIDS; respiratory disorder diagnosis; sputum

Pediatric patients with HIV infection and other immunosuppressive disorders are susceptible to Pneumocystis carinii pneumonia. Bronchoscopy with bronchoalveolar lavage may be technically more difficult to perform in pediatric patients. Because of this, an alterative diagnostic method which was safe and reliable had to be determined. Based on our adult data in which sputum induction has been shown to be a safe and highly sensitive procedure, we have undertaken a prospective assessment of the utility of sputum induction for the diagnosis of P. carinii pneumonia in children. A similar ultrasonic nebulization technique using hypertonic sodium chloride with either expectoration, oropharyngeal or nasopharyngeal suctioning has been employed. Data indicate that P. carinii can be reliably diagnosed by this technique in children as young as one year. The technique is a very safe and effective alternative to bronchoscopy for children. Initial data from this study have appeared in the Journal of Pediatrics. The project is ongoing, and a major goal is to further improve the sampling technique in order to increase sensitivity.

患有HIV感染和其他免疫抑制障碍的儿童患者 容易感染卡氏肺孢子虫肺炎。支气管镜检查 从技术上讲，支气管肺泡灌洗可能更难进行 儿科病人。正因为如此，一种替代的诊断方法 是安全可靠的，必须确定。根据我们的成人数据 哪种诱导痰已被证明是安全和高度敏感的 程序，我们已经进行了一项前瞻性评估的效用 诱导痰对儿童卡氏肺炎的诊断价值。一个 使用高渗氯化钠的类似超声雾化技术 无论是咳痰，口咽或鼻咽吸痰 已经被雇佣了。数据表明，卡氏肺孢子虫可以通过 这项技术适用于年仅一岁的儿童。这项技术是一种非常 安全有效的儿童支气管镜检查替代品。初始数据 已发表在《儿科学杂志》上。该项目是 正在进行中，主要目标是进一步改进抽样技术 以提高灵敏度。