DIAGNOSIS OF PNEUMOCYSTIS CARINII BY INDUCED SPUTUM IN IMMUNOSUPPRESSED CHILDREN

免疫抑制儿童卡氏肺囊虫的诱导痰诊断

• 批准号: 3874251
• 负责人: F P OGNIBENE
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874251
• 关键词: AIDS; Pneumocystis; Pneumocystis pneumonia; child (0-11); diagnosis design /evaluation; diagnosis procedure safety; human subject; longitudinal human study; microorganism classification; opportunistic infections; respiratory disorder diagnosis; sputum

Pediatric patients with AIDS and other immunosuppressive disorders are susceptible to Pneumocystis.carinii pneumonia. Bronchoscopy with bronchoalveolar lavage may be technically more difficult to perform in pediatric patients and may be associated with more morbidity. Because of this, an alterative diagnostic method which was safe and reliable had to be determined. Based on our adult data in which sputum induction has been shown to be a safe and highly sensitive procedure, we have undertaken a prospective assessment of the utility of sputum induction for the diagnosis of P. carinii pneumonia in children. A similar ultrasonic nebulization technique using hypertonic saline with either expectoration, oropharyngeal or nasopharangeal suctioning has been employed. Data indicates that P. carinii can be reliably diagnosed by this technique in children as young as one year. The technique is a very safe and effective alternative to bronchoscopy for children. Initial data from this study have appeared in the Journal of Pediatrics. The project is ongoing, and a major goal is to improve the sampling technique in order to increase sensitivity.

患有艾滋病和其他免疫抑制疾病的儿科患者有 易患肺孢子虫病。卡氏肺炎。支气管镜检查 从技术上讲，支气管肺泡灌洗可能更难进行 儿科患者，并可能与更多的发病率有关。因为. 这，一种安全可靠的替代诊断方法不得不 要下定决心。基于我们成人的数据，在这些数据中诱导痰 证明是一种安全和高度敏感的手术，我们已经进行了 诱导痰用于临床治疗的前瞻性评价 儿童卡氏肺炎性肺炎的诊断。一种类似的超声波 使用高渗盐水雾化技术， 口咽部或鼻咽部吸引术已被采用。数据 表明该技术可用于卡氏肺吸虫的可靠诊断。 年仅一岁的儿童。该技术是一种非常安全有效的 儿童支气管镜检查的替代方法。这项研究的初始数据 已发表在《儿科杂志》上。该项目正在进行中，并且 主要目标是改进抽样技术，以增加 敏感度。