NEBULIZATION TECHNIQUE FOR AEROSOLIZATION OF PENTAMIDINE

虽然喷他脒雾化剂能有效地限制呼吸道感染的发生， 卡氏肺孢子虫（PC）肺炎，其使用实际上可能与 优先表现为PC引起的肺上叶肺炎 这可能是 喷他脒的肺分布模式的函数， 常规（Respirgard II）雾化器。 在这项初步研究中， 将评估一种新的雾化器（Babington型号），并与 常规雾化器。 此外，还将尝试量化 喷他脒地理分布，使用核医学扫描 技术和化学方法，使用支气管肺泡灌洗分析。 的 本前瞻性研究的目的是确定雾化方式 这最有效地允许药物在肺部均匀分布， 并且在这样做时，患者最好耐受。 有效性不是 在这项研究中解决。

Although aerosolized pentamidine is effective in limiting the occurrence of Pneumocystis carinii (PC) pneumonia, its use may actually be associated with preferentially manifested upper lobe pneumonia due to PC. This may be a function of the pattern of lung distribution of pentamidine by the conventional (Respirgard II) nebulizer. In this pilot study, tolerance of a new nebulizer (Babington model) will be assessed and compared with the conventional nebulizer. In addition, there will be an attempt to quantify pentamidine distribution geographically, using nuclear medicine scanning techniques and, chemically, using bronchoalveolar lavage analysis. The goal of this prospective study is to determine the mode of nebulization that most effectively allows for equal pulmonary distribution of the drug, and, in doing so, is best tolerated by the patient. Efficacy is not being addressed in this study.