NEBULIZATION TECHNIQUE FOR AEROSOLIZATION OF PENTAMIDINE

尽管雾化喷雾剂喷雾剂能有效地限制 卡氏肺孢子虫(PC)肺炎，它的使用实际上可能与 以PC引起的上叶肺炎为首发表现。这可能是 肺组织分布模式对戊二胺分布的影响 常规(Respirgard II)雾化器。在这项先导研究中，对 将对一种新的雾化器(巴宾顿模型)进行评估，并与 常规雾化器。此外，还将尝试量化 用核医学扫描技术研究五烷胺在地理上的分布 技术，并在化学上使用支气管肺泡灌洗分析。这个 这项前瞻性研究的目的是确定雾化的方式 这最有效地允许药物在肺内均匀分布， 而且，在这样做的过程中，患者最能耐受。药效不是 在这项研究中提到的。

Although aerosolized pentamidine is effective in limiting the occurrence of Pneumocystis carinii (PC) pneumonia, its use may actually be associated with preferentially manifested upper lobe pneumonia due to PC. This may be a function of the pattern of lung distribution of pentamidine by the conventional (Respirgard II) nebulizer. In this pilot study, tolerance of a new nebulizer (Babington model) will be assessed and compared with the conventional nebulizer. In addition, there will be an attempt to quantify pentamidine distribution geographically, using nuclear medicine scanning techniques and, chemically, using bronchoalveolar lavage analysis. The goal of this prospective study is to determine the mode of nebulization that most effectively allows for equal pulmonary distribution of the drug, and, in doing so, is best tolerated by the patient. Efficacy is not being addressed in this study.