CLINICAL STUDIES OF ABNORMAL HOST DEFENSE

宿主防御异常的临床研究

• 批准号: 3803099
• 负责人: J I GALLIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3803099
• 关键词: Aspergillus; aspergillosis; child (0-11); chronic granulomatous disease; human subject; human therapy evaluation; hyperglobulinemia; interferons; leukocyte disorder; metabolism disorder chemotherapy; neutrophil; opportunistic infections; phagocytosis; sulfamethoxazole; trimethoprim

The purpose of these studies was to study patients with abnormal host defense. In FY '91 studies focused mostly on patients with abnormal phagocytic cell function. Particular emphasis was given to patients with chronic granulomatous disease of childhood (CGD), who are the subject of intense study in the Laboratory of Host Defenses. Some of the clinical observations that were made this year included the following: Demonstration of invasive infection with Sarcinosporon inkin in a patient with CHD; demonstration that normal and abnormal neutrophils can cooperate to damage Aspergillus fumigatus, an observation with important clinical implications for use of white cell transfusions in CGD; demonstration that patients with CGD receiving long term prophylaxis with trimethoprim-sulfamethoxazole have reduced frequency of infection against catalase positive bacteria without increased incidence of fungal infection; completion of long term reviews of skeletal involvement by infection in CGD and anesthesia considerations in CGD; the clinical efficacy of in Gamma-interferon in CGD was demonstrated. We continue to monitor and expand these cohorts of patients as well as patients with leukocyte adhesion deficiency and the syndrome of hyperimmunoglobulin-E and recurrent infections.

这些研究的目的是研究宿主异常的患者 防御。 91 财年的研究主要集中在患有异常的患者 吞噬细胞功能。 特别重视患者 患有儿童慢性肉芽肿病 (CGD) 的人 宿主防御实验室深入研究的课题。 一些 今年进行的临床观察包括 以下： 肉球菌侵入性感染的演示 患有先心病（CHD）的患者；证明正常和异常 中性粒细胞可以合作破坏烟曲霉， 对白细胞的使用具有重要临床意义的观察结果 CGD 中的输血；证明 CGD 患者接受长期治疗 甲氧苄氨嘧啶-磺胺甲恶唑的足月预防已减少 无过氧化氢酶阳性细菌的感染频率 真菌感染的发生率增加；完成长期审查 CGD 和麻醉中感染导致骨骼受累的情况 CGD 中的考虑因素； γ-干扰素的临床疗效 CGD得到了证明。 我们将继续监控和扩大这些群体 患者以及白细胞粘附缺陷患者 高免疫球蛋白-E 综合征和反复感染。