RADIATION THERAPY WITH RADIOLABELLED ANTIBODIES--TECHNICAL ASPECTS AND DOSIMETRY

给药放射性标记抗体是一种相对较新的治疗方法。 治疗某些形式的癌症的方法。这块土地的大部分是 发育性的具有发展性的尤其是肿瘤肿块的剂量学， 尤其是在微观层面上，还处于未知的状态。辐射 物理和计算机自动化科正在积极协助 执行临床方案。目前的研究主要有两个方面 区域。 在时间基础上的特定器官分布模式的成像 是理解抗体动力学的基础，而且对于 体积辐射剂量学(在总器官水平)。有能力 利用核医学精确定位生物分布模式 成像技术，并准确地配准这些图像 到其他成像方式(CT或MRI)是获得 量化结果。 显微肿瘤肿块的剂量测定是通过使用 计算机建模。在可能的情况下，将使用以下方法验证结果 定量放射自显影。

Administration of radiolabelled antibodies is a relatively new treatment modality for certain forms of cancer. Much of this field is developmental in nature. In particular, the dosimetry of tumor masses, especially at the microscopic level, is at yet unknown. The Radiation Physics and Computer Automation Section is actively assisting in the implementation of clinical protocols. Current research is in two major areas. Imaging of the organ-specific distribution patterns on a temporal basis is fundamental to the understanding of antibody kinetics and for large volume radiation dosimetry (at the total organ level). The ability to accurately localize biodistribution patterns using nuclear medicine imaging techniques and to accurately register these images with respect to other imaging modalities (CT or MRI) is essential for obtaining quantitative results. Dosimetry of microscopic tumor masses is approached through the use of computer modeling. The results, where possible, will be validated using quantitative autoradiography.