RADIATION THERAPY WITH RADIOLABELLED ANTIBODIES--TECHNICAL ASPECTS AND DOSIMETRY

给药放射性标记抗体是一种相对较新的方法 治疗某些形式癌症的方式。这一领域的大部分 在本质上是发展的。特别是肿瘤的剂量学 质量，特别是在微观层面上的质量，目前还是未知的。 辐射物理和计算机自动化科正在积极 协助执行临床方案。当前 研究主要集中在两个领域。 颞叶上器官特异性分布模式的成像 基础是理解抗体动力学和 用于大体积辐射剂量测定(在总器官水平)。 准确定位生物分布模式的能力 核医学成像技术与准确配准 这些图像与其他成像方式(CT或MRI)相比 对于获得定量结果是必不可少的。 探讨了显微肿瘤肿块的剂量学方法。 计算机建模技术的发展。如果可能，结果将是 使用定量放射自显影进行了验证。

Administration of radiolabelled antibodies is a relatively new treatment modality for certain forms of cancer. Much of this field is developmental in nature. In particular, the dosimetry of tumor masses, especially at the microscopic level, is as yet unknown. The Radiation Physics and Computer Automation Section is actively assisting in the implementation of clinical protocols. Current research is in two major areas. Imaging of the organ-specific distribution patterns on a temporal basis is fundamental to the understanding of antibody kinetics and for large volume radiation dosimetry (at the total organ level). The ability to accurately localize biodistribution patterns using nuclear medicine imaging techniques and to accurately register these images with respect to other imaging modalities (CT or MRI) is essential for obtaining quantitative results. Dosimetry of microscopic tumor masses is approached through the use of computer modeling. The results, where possible, will be validated using quantitative autoradiography.