RADIATION THERAPY WITH RADIOLABELLED ANTIBODIES--TECHNICAL ASPECTS AND DOSIMETRY

放射性标记抗体的管理是一个相对较新的 某些癌症的治疗方式。 这在很大程度 自然界是发展的。 特别是， 肿瘤块，特别是在微观水平上， 未知 辐射物理与计算机自动化 科正积极协助实施临床 协议. 目前的研究主要集中在两个方面。 成像 器官特异性分布模式的时间基础上， 这是理解抗体动力学和 大体积辐射剂量测定（在整个器官水平）。 的 能够准确定位生物分布模式， 核医学成像技术，并准确配准 这些图像相对于其他成像模态（CT或 MRI）对于获得定量结果至关重要。 此外，本发明还 最好采用显微肿瘤块的剂量测定法， 通过使用计算机建模。 结果，其中 可能的话，将使用定量放射自显影进行验证。

Administration of radiolabelled antibodies is a relatively new treatment modality for certain forms of cancer. Much of this field is developmental in nature. In particular, the dosimetry of tumor masses, especially at the microscopic level, is as yet unknown. The Radiation Physics and Computer Automation Section is actively assisting in the implementation of clinical protocols. Current research is in two major areas. Imaging of the organ-specific distribution patterns on a temporal basis is fundamental to the understanding of antibody kinetics and for large volume radiation dosimetry (at the total organ level). The ability to accurately localize biodistribution patterns using nuclear medicine imaging techniques and to accurately register these images with respect to other imaging modalities (CT or MRI) is essential for obtaining quantitative results. Additionally, the dosimetry of microscopic tumor masses is best approached through the use of computer modelling. The results, where possible, will be validated using quantitative autoradiography.