GENETICS AND VIROLOGY OF CANCER

癌症的遗传学和病毒学

• 批准号: 3092940
• 负责人: HILARY KOPROWSKI
• 金额: $ 136.16万
• 依托单位: WISTAR INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-01 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3092940
• 关键词: neoplasm /cancer genetics; oncogenic virus; virus genetics

This program project proposal Virology and Genetics of Cancer focuses on the use of molecular genetic techniques to investigate the role of viral and cellular oncogenes in the pathogenesis and biology of human cancer. It also addresses the question of how specific oncogenes inserted in the appropriate retrovirus vectors may affect the differentiation program of stem cells. As a result of the previous studies on the expression of tumor associated antigens on gastrointestinal tumors and on the anti-tumor action of monoclonal antibodies directed against antigens expressed on human cells, we also propose new immunotherapeutic approaches to the treatment of human cancer.

本计划项目建议书癌症病毒学与遗传学 重点关注使用分子遗传技术来研究 病毒和细胞癌基因在发病机制中的作用， 人类癌症生物学 它还解决了如何 插入适当逆转录病毒载体中的特定癌基因 可能影响干细胞的分化程序。 因此 以往关于肿瘤相关基因表达的研究， 抗原对胃肠道肿瘤和抗肿瘤作用的影响 针对表达在 人类细胞，我们还提出了新的免疫方法， 人类癌症的治疗