SV40 as a human oncogenic virus. Molecular epidemiology in Japan and Asia.

点击翻译按钮获取中文摘要

The significance of SV40 as an oncogenic vrus was evaluated in mesothelioma and menigioma of Japan, Korea, and Taiwan by PCR of SV40-DNA. PQ, SV and NK fragments of SV40-DNA were amplified in 7, 0 and 0 cases of 35 Japanese mesotheliomas, Four Korean and five Taiwan mesotheliomas showed no amplification of three fragments of SV40. On the other hand, NK fragments were amplified in low frequencies, 3.1% (5/159) in Japanese and 2.5% (6/244) in Korean meningiomas. SV40 has little relationship with mesotheliomas in Japan, Korea, and Taiwan. On the other hand, SV40 has definite relationship with menngiomas in Japan and Korea with low frequencies, suggesting necessity for further molecular epidemiologies on this topic.