IDENTIFICATION OF OXACILLIN RESISTANT STRAINS OF STAPHYLOCOCCUS AUREUS

一项对苯唑西林耐药金黄色葡萄球菌的多中心研究已经到位 应该在一年内完成。噬菌体类型一直是，并将继续下去 用于对苯唑西林耐药菌株进行指纹图谱分析。我们 有证据表明苯唑西林耐药菌株不能通过 克拉维酸数量很少，且耐苯唑西林金黄色葡萄球菌 在美国许多医院都是由一种主要菌株代表的。S. 金黄色葡萄球菌中苯唑西林耐药性在存在的情况下降低 克拉维酸，高β-内酰胺酶的生产者，还有另一个独特的 噬菌体模式。我们还在研究苯唑西林耐药性的损失率。 在从治疗的患者身上培养出菌株后。这一阶段将 包括直接从临床样本中进行初始敏感性测试， 然后是在连续继代培养过程中进行的测试。这一点很重要 影响这些金黄色葡萄球菌菌株的敏感性测试，因为它们开始 在最初的培养中，立即失去抵抗力。

A multi-center study of oxacillin resistant S. aureus is in place and should be completed within a year. Phage types have been, and will continue to be used to fingerprint strains of the oxacillin resistant species. We have evidence that strains with oxacillin resistance not reversible by clavulanic acid are few in number, and that oxacillin resistant S. aureus is represented in many U.S. hospitals by a single predominant strain. S. aureus in which oxacillin resistance is reduced in the presence of clavulanic acid, the hyperbetalactamase producers, have another, distinct phage pattern. We also are studying loss rates of oxacillin resistance after the strains are cultured from the treated patient. This phase will include initial sensitivity tests done directly from clinical samples, followed by tests done during serial subcultures. This has important bearing on sensitivity testing of these S. aureus strains, since they begin to lose resistance immediately, on initial cultures.