BLASTOCYSTIS HOMINIS--STRUCTURE, PHYSIOLOGY AND PATHOGENICITY

人芽囊菌——结构、生理学和致病性

• 批准号: 3916508
• 负责人: C H ZIERDT
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3916508
• 关键词: Coccidia; anaerobic bacteria; carbohydrate metabolism; communicable disease diagnosis; cytochrome c; diarrhea; electron microscopy; epidemiology; feces analysis; gastrointestinal agents; gastrointestinal disorder chemotherapy; human subject; life cycle; metronidazole; microorganism disease chemotherapy; mitochondria; polysaccharides; protozoal infection; protozoal toxin; sulfamethoxazole; virulence

Work over the pat 17 years has reclassified Blastocystis hominis as a protozoan, removing it from the yeasts where it has languished for 70 years. B. hominis now is established firmly as a member of the Sporozoa, and intestinal parasite and pathogen of man and primates. This protozoan is now a subject of national and international interest to parasitologists and physicians as a cause of diarrhea in man. Treatment is usually with metronidazole. Trimethoprim- sulfamethoxazole also is used successfully. Ultrastructural evidence has proven that B. hominis mitochondria are indeed typical mitochondria. It has been stated that the B. hominis organelle was not a mitochondrion since the tubular cristae appeared to open to the outside; Dr. J. Muller, using special techniques, provided clear photographs of the enveloping outer membrane. Data collected over 1986-87 include: 1. Positive correlation between added cytochrome C and mitochondria numbers, and uptake of carbohydrate metabolites; 2. Purification and partial analysis of a polysaccharide slime material synthesized by Blastocystis.

17年来的工作重新分类了人芽囊原虫 作为一种原生动物，将其从酵母中取出， 70年来， B。人类现在已经牢固地确立了 孢子虫的成员，肠道寄生虫和病原体 人与灵长类 这种原生动物现在是国家和国际的主题， 寄生虫学家和医生的兴趣作为腹泻的原因， 伙计 治疗通常是甲硝唑。 甲氧苄啶 磺胺甲恶唑也被成功地使用。 超微结构证据证明B.人线粒体 是典型的线粒体 已经指出，B. 人的细胞器不是一个细胞器，因为管状 嵴似乎向外部开放; J. Muller博士，使用 特殊技术，提供了包裹的清晰照片 外膜 一九八六至八七年收集的数据包括： 1. 添加的细胞色素C与 线粒体数量和碳水化合物代谢物的摄取; 2. 一种多糖粘泥的纯化及部分分析 由芽囊原虫合成的物质。