BLASTOCYSTIS HOMINIS--STRUCTURE, PHYSIOLOGY AND PATHOGENICITY

人芽囊菌——结构、生理学和致病性

• 批准号: 3874332
• 负责人: C H ZIERDT
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874332
• 关键词: Coccidia; aconitate hydratase; alpha ketoglutarate; anaerobic bacteria; cholesterol; cytochrome oxidase; diarrhea; electron microscopy; feces analysis; flavoproteins; glucose dehydrogenases; glutamate dehydrogenase; metronidazole; microorganism metabolism; mitochondria; molecular pathology; pathology; protozoa; protozoal infection; pyruvate dehydrogenase; virulence

B hominis mitochondria have no lactic dehydrogenase, isocitrate dehydrogenase, glycerol dehydrogenase, cytochrome C oxidase, glutamate dehydrogenase, dihydrolipoemide dehydrogenase, alpha keto-glutarate dehydrogenase, or pyruvate dehydrogenase enzymatic activity. B hominis has an absolute requirement for cholesterol. The main acid products from glucose are acetic, propionic, succinic, lactic, and isovaleric acids. Spectrographic analysis for cytochromes and flavoprotein was negative. Thus, these mitochondria lack enzymes, as well as cytochromes that are normally present in mitochondria.

B hominis线粒体无乳酸脱氢酶、异柠檬酸 脱氢酶，甘油脱氢酶，细胞色素C氧化酶，谷氨酸 α-酮戊二酸脱氢酶 脱氢酶或丙酮酸脱氢酶酶活性。 B hominis对胆固醇有绝对的需求。主要酸 葡萄糖的产物是乙酸、丙酸、琥珀酸、乳酸和 异戊酸 细胞色素和黄素蛋白的光谱分析为阴性。 因此，这些线粒体缺乏酶，以及细胞色素， 通常存在于线粒体中。