CLINICAL STUDIES ON INTRAOPERATIVE RADIATION THERAPY

术中放射治疗的临床研究

• 批准号: 3874415
• 负责人: E GLATSTEIN
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874415
• 关键词: carcinoma; combination cancer therapy; drug administration routes; human subject; human therapy evaluation; lung neoplasms; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; pancreas neoplasms; peritoneum neoplasm; radiation therapy dosage; sarcoma; stomach neoplasms

The Radiation Oncology Branch and Surgery Branches of the National Cancer Institute have been involved in prospectively randomized studies evaluating the potential role of intraoperative radiation therapy in several disease sites, including resectable and unrespectable carcinomas of the pancreas, resectable carcinomas of the stomach, and retroperitoneal sarcomas. One hundred patients have been treated with experimental intraoperative radiation therapy, and randomized to either receive or not receive radiation therapy intraoperatively with large single doses of electrons. There is really no suggestion of improvement in survival, or in disease-free survival. There is some suggestion of an Improvement of local control in the retroperitoneum itself; however, this is off-set by a high predilection for seeding of the abdominal cavity, either peritoneal carcinomatosis or sarcomatosis, thus neutralizlng the potential benefit of intraoperative radiation. The trials on pancreatic carcinoma and retroperitoneal sarcomas have been closed. The gastric study is still open for patient accrual.

美国国家癌症研究所放射肿瘤学分支和外科分支 研究所参与了前瞻性随机研究， 术中放射治疗在几种疾病中潜在作用 部位，包括可切除和不可切除的胰腺癌， 可切除的胃癌和腹膜后肉瘤。一 数百名患者接受了实验性术中 放射治疗，并随机接受或不接受 术中用大剂量电子进行放射治疗。 没有任何迹象表明生存率或 无病生存率有一些建议，以改善当地的 控制在腹膜后本身;然而，这是抵消了高 倾向于腹腔接种，无论是腹膜 癌病或肉瘤病，从而中和了 术中放疗。胰腺癌的试验和 腹膜后肉瘤已经闭合。胃部研究还在进行中 患者的累积。