CLINICAL STUDIES ON INTRAOPERATIVE RADIATION THERAPY

国家癌症放射肿瘤学分会和外科分会 研究所参与了前瞻性随机研究，评估 术中放射治疗在几种疾病中的潜在作用 包括可切除的和不受尊重的胰腺癌， 可切除的胃癌和腹膜后肉瘤。一 已有数百名患者接受了实验性的术中治疗 放射治疗，随机接受或不接受 术中大剂量单次电子放射治疗。 确实没有任何迹象表明存活率或 无病生存。有一些建议可以改善当地的 控制在腹膜后本身；然而，这是抵消的高 腹膜或腹膜腔内种植的首选 癌病或肉瘤病，从而抵消了 术中放射治疗。关于胰腺癌和胰腺癌的临床试验 腹膜后肉瘤已经关闭。胃部研究仍在进行中 为病人带来的收益。

The Radiation Oncology Branch and Surgery Branches of the National Cancer Institute have been involved in prospectively randomized studies evaluating the potential role of intraoperative radiation therapy in several disease sites, including resectable and unrespectable carcinomas of the pancreas, resectable carcinomas of the stomach, and retroperitoneal sarcomas. One hundred patients have been treated with experimental intraoperative radiation therapy, and randomized to either receive or not receive radiation therapy intraoperatively with large single doses of electrons. There is really no suggestion of improvement in survival, or in disease-free survival. There is some suggestion of an Improvement of local control in the retroperitoneum itself; however, this is off-set by a high predilection for seeding of the abdominal cavity, either peritoneal carcinomatosis or sarcomatosis, thus neutralizlng the potential benefit of intraoperative radiation. The trials on pancreatic carcinoma and retroperitoneal sarcomas have been closed. The gastric study is still open for patient accrual.