CLINICAL STUDIES ON INTRAOPERATIVE RADIATION THERAPY

术中放射治疗的临床研究

• 批准号: 3853177
• 负责人: E GLATSTEIN
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853177
• 关键词: carcinoma; clinical trials; combination cancer therapy; human subject; human therapy evaluation; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; pancreas neoplasms; peritoneum neoplasm; radiation therapy dosage; sarcoma; stomach neoplasms

The Radiation Oncology Branch and Surgery Branches of the National Cancer Institute have been involved in prospectively randomized studies evaluating the potential role of intraoperative radiation therapy in several disease sites, including resectable and unresectable carcinomas of the pancreas, resectable carcinomas of the stomach, and retroperitoneal sarcomas. One hundred patients have been treated with experimental intraoperative radiation therapy, and randomized to either receive or not receive radiation therapy intraoperatively with large single doses of electrons. There is really no suggestion of improvement in survival, or in disease-free survival. There is some suggestion of an improvement of local control in the retroperitoneum itself; however, this is off-set by a high predilection for seeding of the abdominal cavity, either peritoneal carcinomatosis or sarcomatosis, thus neutralizing the potential benefit of intraoperative radiation. The trials on pancreatic carcinoma and retroperitoneal sarcomas have been closed. The gastric study is still open for patient accrual.

国家放射肿瘤学分会和外科分会 癌症研究所已经参与了前瞻性随机研究 评价术中放射治疗的潜在作用 几个病变部位，包括可切除和不能切除的癌 胰腺癌，可切除的胃癌，以及 腹膜后肉瘤。已有100名患者接受了 实验性的术中放射治疗，随机分为两组 术中接受或不接受放射治疗 单剂量的电子。确实没有任何改善的迹象。 在生存中，或在无疾病的生存中。有一些建议是 腹膜后局部控制的改善；然而， 这被腹部播种的高度偏好所抵消。 空洞，腹膜癌或肉瘤病，因此 中和术中放射治疗的潜在益处。这个 治疗胰腺癌和腹膜后肉瘤的试验已经完成 关着的不营业的。胃部研究仍对患者开放。