CLINICAL STUDIES ON INTRAOPERATIVE RADIATION THERAPY

术中放射治疗的临床研究

• 批准号: 3838055
• 负责人: E GLATSTEIN
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838055
• 关键词: carcinoma; clinical trials; combination cancer therapy; electron radiation; human mortality; human subject; human therapy evaluation; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; pancreas neoplasms; peritoneum neoplasm; radiation therapy dosage; sarcoma; stomach neoplasms

The Radiation Oncology Branch and Surgery Branches of the National Cancer Institute have been involved in prospectively randomized studies evaluating the potential role of intraoperative radiation therapy in several disease sites, including resectable and unresectable carcinomas of the pancreas, resectable carcinomas of the stomach and retroperitoneal sarcomas. One hundred patients have been treated with experimental intraoperative radiation therapy, and randomized to either receive or not receive radiation therapy intraoperatively with large single doses of electrons. There is really no suggestion of improvement in survival, or in disease-free survival. There is some suggestion of an improvement of local control in the retroperitoneum itself; however, this is off-set by a high predilection for seeding of the abdominal cavity, either peritoneal carcinomatosis or sarcomatosis, thus neutralizing the potential benefit of intraoperative radiation. The trials on pancreatic carcinoma and retroperitoneal sarcomas have been closed. The gastric study is still open for patient accrual.

美国国家癌症研究所放射肿瘤学分支和外科分支 研究所参与了前瞻性随机研究 评估术中放射治疗的潜在作用， 几个疾病部位，包括可切除和不可切除的癌 胰腺癌、可切除的胃癌和腹膜后癌 肉瘤 100名患者接受了实验性的 术中放射治疗，并随机接受或不接受 术中接受大剂量单次放射治疗 电子。 确实没有迹象表明生存率有所改善，或者 无病生存率。 有一些改进的建议， 腹膜后腔本身的局部控制;然而，这被以下因素抵消 腹腔接种的高度偏好， 腹膜癌病或肉瘤病，从而中和 术中放疗的潜在益处。 胰腺癌的临床试验 癌和腹膜后肉瘤已经关闭。 胃 研究仍开放供患者入组。