CLINICAL STUDIES ON INTRAOPERATIVE RADIATION THERAPY

国家放射肿瘤学分会和外科分会 癌症研究所已经参与了前瞻性随机研究 评估术中放射治疗的潜在作用的研究 在几个疾病部位进行治疗，包括可切除和 不能切除的胰腺癌，可切除的 胃和腹膜后肉瘤。一百名病人 已经接受了实验性的术中放射治疗 治疗，随机接受或不接受放射治疗 术中使用大剂量单次电子治疗。 确实没有任何迹象表明存活率或 无病生存。有一些改进的建议 腹膜后自身的局部控制；然而，这是 被腹膜腔内播种的高度偏好所抵消， 要么是腹膜癌，要么是肉瘤，因此中和 术中放射治疗的潜在益处。关于中国的审判 胰腺癌和腹膜后肉瘤已经关闭。 胃部研究仍对患者开放。

The Radiation Oncology Branch and Surgery Branches of the National Cancer Institute have been involved in prospectively randomized studies evaluating the potential role of intraoperative radiation therapy in several disease sites, including resectable and unresectable carcinomas of the pancreas, resectable carcinomas of the stomach, and retroperitoneal sarcomas. One hundred patients have been treated with experimental intraoperative radiation therapy, and randomized to either receive or not receive radiation therapy intraoperatively with large single doses of electrons. There is really no suggestion of improvement in survival, or in disease-free survival. There is some suggestion of an improvement of local control in the retroperitoneum itself; however, this is off-set by a high predilection for seeding of the abdominal cavity, either peritoneal carcinomatosis or sarcomatosis, thus neutralizing the potential benefit of intraoperative radiation. The trials on pancreatic carcinoma and retroperitoneal sarcomas have been closed. The gastric study is still open for patient accrual.