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SYNTHESIS AND PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 5-AZACYTOSINE RESIDUES

SYNTHESIS AND PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 5-AZACYTOSINE RESIDUES
含5-氮杂胞嘧啶残基的寡核苷酸的合成及性质
批准号：
3874391
负责人：
V E MARQUEZ
金额：
$0.0万
依托单位：
DIVISION OF CANCER TREATMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3874391
关键词：
DNA methylation antineoplastics azacitidine cytosine analog drug design /synthesis /production drug metabolism enzyme inhibitors gene expression high performance liquid chromatography nucleic acid chemical synthesis nucleic acid sequence nucleoside analog oligonucleotides oxidation oxidation reduction reaction phosphamide synthetic nucleotide

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中文摘要
翻译
含二氢5-氮胞嘧啶的寡脱氧核苷酸的合成
英文摘要
The synthesis of oligodeoxynucleotides containing a dihydro-5-azacytosine moiety instead of cytosine at any desired position of a sequence in an oligo can now be achieved routinely. A new and efficient preparative HPLC method for the purification of these oligodeoxynucleotides was also developed. Oxidation of the dihydro-5-azacytosine moiety to the aromatic 5-azacytosine has been attempted and continues to be investigated. The target oligodeoxynucleotides containing 5-azacytosine moieties are expected to behave as inhibitors of DNA methylase and to affect gene expression.
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