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SYNTHESIS AND PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 5-AZACYTOSINE RESIDUES

SYNTHESIS AND PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 5-AZACYTOSINE RESIDUES
含5-氮杂胞嘧啶残基的寡核苷酸的合成及性质
批准号：
3916559
负责人：
V E MARQUEZ
金额：
$0.0万
依托单位：
DIVISION OF CANCER TREATMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3916559
关键词：
DNA methylation antineoplastics azacitidine cytosine analog drug design /synthesis /production drug metabolism enzyme inhibitors gene expression nucleoside analog oligonucleotides oxidation reduction reaction phosphamide

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中文摘要
翻译
这项工作的主要目的是发展技术
英文摘要
The main objective of this work is the development of techniques for the incorporation of 5-azacytosine (5-AC) and its reduced analogue 5,6-dihydro-5-azacytosine (DHAC) into specific sites of a synthetic oligonucleotide. The resulting modified oligonucleotides will be studied as specific DNA methylase inhibitors and as probes to study the relationship between DNA methylation and gene expression. A phosphoramidite synthon was synthesized and used in an automated DNA synthesizer to prepare dimers and decamers containing DHAC and 5-AC. Reaction conditions were optimized. An efficient method was developed for the oxidation of DHAC to 5-AC in the oligomers.
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    5201243
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  • 财政年份：
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  • 负责人：
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    DIVISION OF CANCER TREATMENT
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    5201242
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