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THE ANALYTICAL CHEMISTRY OF ANTI-AIDS AGENTS

THE ANALYTICAL CHEMISTRY OF ANTI-AIDS AGENTS
抗艾滋病药物的分析化学
批准号：
3874393
负责人：
J A KELLEY
金额：
$0.0万
依托单位：
DIVISION OF CANCER TREATMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3874393
关键词：
AIDS AIDS therapy adenine analog analytical chemistry antiAIDS agent antiviral agents chemical structure function deoxyadenosines deoxyguanosine drug design /synthesis /production drug metabolism fluorine gas chromatography high performance liquid chromatography hypoxanthines inosine mass spectrometry nucleoside analog pharmacokinetics purine analog

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中文摘要
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英文摘要
The objective of this project is the research and development of suitable analytical methods to: (1) establish the structure and purity of potential anti-AIDS agents and new antiviral drugs, (2) determine physical, chemical and biochemical properties, including octanol-water partition coefficients , of these compounds and their metabolites, and (3) measure these drugs and their metabolites in biological samples to elucidate pharmacology and to determine pharmacokinetics. High-performance liquid chromatography and mass spectrometry are emphasized techniques. Compounds of current interest are dideoxynucleosides including ddG, 6-halo-dd-Purines. 2-NH(2)-6-halo-dd-Purines, 2'-F-dd-ara-A, 2'-F-dd-ara-I, 2'-F-dd-ara-G,2'-F-dd-C, 2'-F-dd-ara-C and 6-substituted-2'-F-dd-Purines.
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APPLICATIONS OF NEW MASS SPECTRAL TECHNIQUES
  • 批准号：
    3838039
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    J A KELLEY
  • 依托单位：
    DIVISION OF CANCER TREATMENT
APPLICATIONS OF NEW MASS SPECTRAL TECHNIQUES
  • 批准号：
    3774555
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    J A KELLEY
  • 依托单位：
    DIVISION OF CANCER TREATMENT
THE ANALYTICAL CHEMISTRY OF ANTI-AIDS AGENTS
THE ANALYTICAL CHEMISTRY OF NEW ANTICANCER DRUGS
  • 批准号：
    3774543
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    J A KELLEY
  • 依托单位：
    DIVISION OF CANCER TREATMENT
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