THE ANALYTICAL CHEMISTRY OF NEW ANTICANCER DRUGS

该项目的目标是研究和开发 分析方法，用于：（1）建立结构和 新的抗肿瘤药物及其代谢产物的纯度，（2）确定 抗癌新药的理化性质，（3）定量 药物及其代谢物的生物样品，以阐明 药理学和确定药代动力学，和（4）研究反应 潜在有用的合成转化机制。 质量 光谱法、气相色谱法和高效液相色谱法 单独或组合的色谱法，强调 技术. 目前感兴趣的化合物是环戊烯基胞嘧啶 生物化学、临床前和临床药理学和方法 增强），卡波丁/异卡波丁（立体定向合成和 分析表征）和修饰的核苷（分析 表征，端基异构体和异构体的纯化，分配 系数评价）。

The objective of this project is the research and development of analytical methods which are used to: (1) establish the structure and purity of new antitumor agents and their metabolites, (2) determine physical and chemical properties of new anticancer drugs, (3) quantitate drugs and their metabolites in biological samples to elucidate pharmacology and to determine pharmacokinetics, and (4) study reaction mechanisms of potentially useful synthetic transformations. Mass spectrometry, gas chromatography and high-performance liquid chromatography, either alone or in combination, are emphasized techniques. Compounds of current interest are cyclopentenyl cytosine (biochemistry, preclinical and clinical pharmacology, and methods enhancement), carbodine/isocarbodine (stereospecific synthesis and analytical characterization), and modified nucleosides (analytical characterization, purification of anomers and isomers, partition coefficient evaluation).