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THE ANALYTICAL CHEMISTRY OF NEW ANTICANCER DRUGS

THE ANALYTICAL CHEMISTRY OF NEW ANTICANCER DRUGS
新抗癌药物的分析化学
批准号：
3916542
负责人：
J A KELLEY
金额：
$0.0万
依托单位：
DIVISION OF CANCER TREATMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3916542
关键词：
analytical method antineoplastics cell differentiation chemical structure function clinical chemistry combination chemotherapy cytidine dogs drug metabolism drug screening /evaluation enzyme inhibitors gas chromatography high performance liquid chromatography human tissue laboratory rat mass spectrometry mechlorethamine neoplasm /cancer pharmacology nitrogen mustard nucleoside analog oligonucleotides pharmacokinetics pyrimidine analog pyrimidine nucleosides uridine

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中文摘要
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英文摘要
The objective of this project is the research and development of analytical methods which are used to: (1) establish the structure and purity of new antitumor agents and their metabolites, (2) determine physical and chemical properties of new anticancer drugs, (3) quantitate drugs and their metabolites in biological samples to elucidate pharmacology and to determine pharmacokinetics, and (4) study reaction mechanisms of potentially useful synthetic transformations. Mass spectrometry, gas chromatography and high- performance liquid chromatography, either alone or in combination, are emphasized techniques. Compounds of current interest are cytidine analogs, modified nucleosides, oligonucleotides and differentiating agents.
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APPLICATIONS OF NEW MASS SPECTRAL TECHNIQUES
  • 批准号：
    3838039
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    J A KELLEY
  • 依托单位：
    DIVISION OF CANCER TREATMENT
APPLICATIONS OF NEW MASS SPECTRAL TECHNIQUES
  • 批准号：
    3774555
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    J A KELLEY
  • 依托单位：
    DIVISION OF CANCER TREATMENT
THE ANALYTICAL CHEMISTRY OF ANTI-AIDS AGENTS
THE ANALYTICAL CHEMISTRY OF NEW ANTICANCER DRUGS
  • 批准号：
    3774543
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    J A KELLEY
  • 依托单位：
    DIVISION OF CANCER TREATMENT
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