ANIMAL MODELS FOR THE STUDY OF DEMENTIAS AND AGING

我们的项目涵盖了多学科、但连贯的方法 旨在了解非常规病毒性痴呆 以及它们与“非传染性”痴呆的关系(例如 阿尔茨海默病)。将使用实验性CJD啮齿动物模型 评估感染和进展过程中的危重事件 疾病。同时进行生化和遗传学研究 这里提出了形态和传染性的研究。我们 继续寻找真正的代理特异性(非宿主)分子 (蛋白质和核酸)。我们还希望定义探测器， 将在阿尔茨海默病和CJD的研究中使用。 这样的探测将有助于比较感染性痴呆 与那些病因不明的，并将被用于分析这两个 CJD实验啮齿动物标本和珍贵人体标本， GSS和AD。

Our projects cover a multidisciplinary, but coherent approach directed toward an understanding of unconventional viral dementias and their relationship to "non infectious" dementias (e.g. Alzheimer's disease). Experimental CJD rodent models will be used to evaluate critical events during infection and progression of disease. Biochemical and genetic studies in parallel with morphological and infectivity studies are here proposed. We continue our search for true agent-specific (non-host) molecules (protein and nucleic acid). We also hope to define probes that will be of use in studies of Alzheimer's disease as well as in CJD. Such probes will facilitate comparisons of infectious dementias with those of unknown etiology, and will be used to analyze both experimental rodent material and precious human specimen of CJD, GSS and AD.