Deciphering mechanisms of liver allograft tolerance

解读同种异体肝移植耐受的机制

• 批准号: nhmrc : 1011573
• 负责人: A/Pr David Bowen
• 金额: $ 34.74万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-mechanisms-liver-allograft-tolerance/109600
• 关键词: Deciphering; mechanisms; liver; allograft; tolerance

The liver has paradoxical properties: it is the site of effective immune responses to pathogens, but under some circumstances, it is known to induce harmless immune responses. Liver transplants are more readily accepted than other organ grafts in the absence of immunosuppressive drugs but little is known about the mechanisms that prevent an effective response. This proposal aims to unravel these mechanisms. This project will have important implications for transplantation studies.

肝脏具有矛盾的特性：它是对病原体进行有效免疫反应的场所，但在某些情况下，它已知可以诱导无害的免疫反应。在没有免疫抑制药物的情况下，肝移植比其他器官移植更容易被接受，但人们对阻止有效反应的机制知之甚少。这项提议旨在解开这些机制。该项目将对移植研究具有重要意义。