Protecting against malaria through liver-resident memory T cells

通过肝脏驻留记忆 T 细胞预防疟疾

• 批准号: nhmrc : 1139486
• 负责人: A/Pr David Bowen
• 金额: $ 80.92万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/protecting-malaria-liver-t-cells/1318993
• 关键词: Protecting; against; malaria; through; liver

We have shown that formation of liver-resident memory T cells (Trm), a newly discovered type of immune cells, can be induced by an innovative vaccination strategy called prime and trap for highly efficient protection against malaria in mice. Here, we will enhance prime and trap vaccination efficacy by defining the conditions that maximize liver Trm-mediated protection and will characterize simian and human liver Trm cells, paving the way to create the most efficient human malaria vaccine to date

我们已经证明，肝脏驻留记忆T细胞（Trm）是一种新发现的免疫细胞类型，可以通过一种称为prime和trap的创新疫苗接种策略诱导形成，从而高效地保护小鼠免受疟疾的侵袭。在这里，我们将通过确定最大化肝脏Trm介导的保护的条件来提高初级和陷阱疫苗接种效力，并将表征猿猴和人类肝脏Trm细胞，为创造迄今为止最有效的人类疟疾疫苗铺平道路