Unraveling mechanisms of liver transplant tolerance

揭示肝移植耐受的机制

• 批准号: nhmrc : 1086451
• 负责人: A/Pr David Bowen
• 金额: $ 46.33万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unraveling-mechanisms-liver-transplant-tolerance/519131
• 关键词: Unraveling; mechanisms; liver; transplant; tolerance

Liver transplants are unique amongst solid organs as they are spontaneously accepted across different individuals and induce acceptance of other organs from the same donor co-transplanted at the same time. Using a new mouse liver transplantation model, this proposal will elucidate how the liver tissue performs this function and identify new markers associated with tolerance in the blood of mice. This knowledge will be used to identify liver transplant patients with reduced rejection risk.

肝脏移植在实体器官中是独一无二的，因为它们可以被不同的个体自发接受，并诱导同时接受来自同一供体的其他器官的共同移植。该提案将使用新的小鼠肝移植模型来阐明肝组织如何执行此功能，并确定与小鼠血液中的耐受性相关的新标记物。这些知识将用于识别排斥风险降低的肝移植患者。