Deciphering the overlapping roles of SSB1 and SSB2 in the regulation of haematopoiesis and intestinal homeostasis

破译SSB1和SSB2在造血和肠道稳态​​调节中的重叠作用

• 批准号: nhmrc : GNT1085367
• 负责人: A/Pr Steven Lane
• 金额: $ 95.87万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-overlapping-roles-intestinal-homeostasis/1345620
• 关键词: Deciphering; overlapping; roles; SSB1; SSB2

Our work centres on elucidating the role of two newly identified and related single-stranded DNA binding protein (Ssb1 and Ssb2) in development of blood and gut system. When both genes are deleted mice die with 8 days of knockdown due to bone marrow failure and intestinal atrophy. Our double knockout model parallels the consequences of radiation damage on blood and gut system. Toxicity to these systems is a significant hindrance in delivering anti-tumor therapy.

我们的工作重点是阐明两种新发现的相关单链DNA结合蛋白（Ssb1和Ssb2）在血液和肠道系统发育中的作用。当这两个基因都被删除时，小鼠在8天的基因敲除后会因骨髓衰竭和肠道萎缩而死亡。我们的双敲除模型与辐射对血液和肠道系统的损害的后果相似。对这些系统的毒性是递送抗肿瘤疗法的显著障碍。