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Deciphering the overlapping roles of SSB1 and SSB2 in the regulation of haematopoiesis and intestinal homeostasis

Deciphering the overlapping roles of SSB1 and SSB2 in the regulation of haematopoiesis and intestinal homeostasis
破译SSB1和SSB2在造血和肠道稳态​​调节中的重叠作用
批准号：
nhmrc : 1085367
负责人：
A/Pr Steven Lane
金额：
$66.46万
依托单位：
Queensland Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 2018-12-31
来源：
https://researchdata.edu.au/deciphering-overlapping-roles-intestinal-homeostasis/519080
关键词：
DecipheringoverlappingrolesSSB1SSB2

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中文摘要
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英文摘要
Our work centres on elucidating the role of two newly identified and related single-stranded DNA binding protein (Ssb1 and Ssb2) in development of blood and gut system. When both genes are deleted mice die with 8 days of knockdown due to bone marrow failure and intestinal atrophy. Our double knockout model parallels the consequences of radiation damage on blood and gut system. Toxicity to these systems is a significant hindrance in delivering anti-tumor therapy.
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The evolution of acute myeloid leukaemia by in situ transformation of haematopoietic stem cells
  • 批准号：
    nhmrc : GNT1098470
  • 项目类别：
    Project Grants
  • 资助金额：
    $64.7万
  • 财政年份：
    2016
  • 负责人：
    A/Pr Steven Lane
  • 依托单位：
The evolution of acute myeloid leukaemia by in situ transformation of haematopoietic stem cells
Targeting leukaemia stem cells through inhibition of telomerase
Targeting leukaemia stem cells through inhibition of telomerase
  • 批准号：
    nhmrc : GNT1098516
  • 项目类别：
    Project Grants
  • 资助金额：
    $65.2万
  • 财政年份：
    2016
  • 负责人：
    A/Pr Steven Lane
  • 依托单位：
海外基金