Molecular pathways mediating quiescence and resistance in leukaemia stem cells in acute myeloid leukaemia.

介导急性髓系白血病白血病干细胞静止和抵抗的分子途径。

• 批准号: nhmrc : 511275
• 负责人: A/Pr Steven Lane
• 金额: $ 6.69万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-pathways-mediating-myeloid-leukaemia/115599
• 关键词: Molecular; pathways; mediating; quiescence; resistance

Acute myeloid leukaemia (AML) is a devastating cancer of the blood and bone marrow which is rapidly fatal unless effectively treated with chemotherapy. AML is caused by genetic events that alter normal blood stem cells to give them a growth and survival advantage and also may confer resistance to chemotherapy in some cases. We will evaluate and target the mechanism of this resistance in laboratory models. This information can then be used to design new treatments to improve outcomes in AML.

急性髓性白血病（AML）是一种毁灭性的血液和骨髓癌症，除非用化疗有效治疗，否则会迅速致命。AML是由遗传事件引起的，这些遗传事件改变了正常的造血干细胞，使它们具有生长和生存优势，并且在某些情况下还可能对化疗产生抗性。我们将在实验室模型中评估和靶向这种耐药性的机制。然后，这些信息可以用于设计新的治疗方法，以改善AML的预后。