TUMOR SUPPRESSION GENES AND ANTI-METASTASIS IN HUMAN CARCINOGENESIS

p53肿瘤抑制基因在大多数人中是突变的。 癌的 p53的改变是原发性肝癌发病的早期事件。 多期肺癌和食管癌。 的突变谱 p53在不同的人类癌症类型中，在某些情况下，突变是 环境致癌物暴露的DNA指纹 初步成效 表明肺癌中p53突变谱与 铀矿工和非矿工吸烟者。 对p53功能的机制研究表明，某些突变型p53 基因可导致人类支气管上皮细胞的肿瘤转化 细胞 这些结果与突变 在p53中的缺失可导致肿瘤抑制功能的丧失和癌基因的获得 功能

The p53 tumor suppressor gene is mutated in the majority of human cancers. Alterations in p53 are an early event in the pathogenesis of multistage lung and esophageal carcinomas. The mutational spectrum of p53 in different human cancer types and, in some cases, the mutations are a DNA fingerprint of environmental carcinogen exposure. Initial results indicate differences in p53 mutational spectra in lung cancers from uranium miners versus non-miner cigarette smokers. Mechanistic studies of p53 function have shown that certain mutant p53 genes can cause neoplastic transformation of human bronchial epithelial cells. These results are consistent with the hypothesis that mutations in p53 can lead to loss of tumor suppressor function and gain of oncogene function.