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PRODUCTION OF METALLOPROTEINASES AND TIMP1 BY GLOMERULAR CELLS

PRODUCTION OF METALLOPROTEINASES AND TIMP1 BY GLOMERULAR CELLS
肾小球细胞产生金属蛋白酶和 TIMP1
批准号：
3840307
负责人：
L J STRIKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3840307
关键词：
cell growth regulation collagenase diabetic nephropathy endopeptidases enzyme inhibitors extracellular matrix genetically modified animals glomerulonephritis kidney cell laboratory mouse messenger RNA metalloenzyme molecular pathology nephrocalcinosis protein degradation renal glomerulus somatotropin tissue /cell culture

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英文摘要
Glomerulosclerosis occurs in a large number of human kidney diseases, including diabetic nephropathy. It consists of the accumulation of extracellular matrix (ECM) within the glomerulus. Sclerosis may be mediated by dysregulation of both synthesis and degradation of ECM. A large family of matrix metalloproteinases as well as tissue inhibitors of metalloproteinase (TIMPs) play a role in the degradative process. Our preliminary work reveals that: 1) normal mouse mesangial cells in culture secrete a 72 kD and a 92 kD gelatinase (type IV collagenase) as well as TIMP1; 2) mesangial cells derived form NOD mice and mice transgenic for bovine growth hormone (bGH) secrete only the 72 kD gelatinase; and 3) TIMP1 mRNA levels are modulated by cell density.
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PRODUCTION OF METALLOPROTEINASES AND TIMPS BY GLOMERULAR CELLS
GLOMERULAR LESIONS IN NON-OBESE DIABETIC MICE
PRODUCTION OF METALLOPROTEINASES AND TIMPS BY GLOMERULAR CELLS
DEGRADATION OF EXTRACELLULAR MATRIX IN HUMAN GLOMERULI
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