STUDY OF GLYCOGEN STORAGE DISEASE

在这项研究的早期阶段发现， 玉米淀粉可以维持I型糖尿病患者的正常血糖 肝葡萄糖生成不足的GSD。相关联的 政府物料供应处的调查结果，例如，生长障碍，低血糖，肝腺瘤， 都可以通过这种疗法得到纠正或改善许多不同的 尝试了各种类型的淀粉和淀粉方案，但几乎没有 例外的是未煮过的玉米淀粉提供了最好的结果。 随着越来越多的患者活得更长，更多的相关疾病开始出现。 出现很明显，局灶性肾小球硬化是非常严重的。 常见于老年人，并导致肾衰竭死亡。 已添加到列表中的其他相关条件 包括肾结石、全身性脱矿、贫血、异常 粒细胞功能，中央性卵巢功能衰竭，原发性肺动脉高压 高血压和淀粉样蛋白沉积。疾病的这一方面成为 更引人注目的是，人们认为玉米淀粉处理阶段 被世界公认为首选治疗方法。 因此，方案中止。

It was found in the early phases of this study that oral uncooked cornstarch could sustain a normal blood glucose in patients with type I GSD whose liver glucose production was inadequate. The associated findings of GSD, e.g., growth failure, hypoglycemia, liver adenomata, could be corrected or improved with this regimen. A number of different types of starch and starch regimens were tried but almost without exception uncooked cornstarch provided the best results. As more patients lived longer, more associated disorders began to appear. It became apparent that focal glomerular sclerosis was very frequent in older individuals and it led to death with renal failure. Additional associated conditions which have since been added to the list include renal stones, generalized demineralization, anemia, abnormal granulocyte function, central ovarian failure, primary pulmonary hypertension, and amyloid deposition. This facet of the disease became much more compelling and it was felt that the cornstarch treatment phase was completed with worldwide acceptance as the treatment of choice. Hence, the protocol was discontinued.