Standing up for Dementia: exchanging knowledge on developing a patient and professional pathway for physical activity and exercise.

支持痴呆症：交流有关开发患者和专业体育活动和锻炼途径的知识。

• 批准号: ES/K007688/1
• 负责人: Michael Trenell
• 金额: $ 12.8万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ES%2FK007688%2F1
• 关键词: Standing; up; Dementia; exchanging; knowledge

Dementia is currently a major healthcare problem. As our population ages, the number of people suffering from dementia increases yearly. This comes at both a large human and financial cost. Currently, there is no cure for dementia but medication can help to delay the progress of the disease although this has varying degrees of success - other treatment options which involve the patient more directly in their own care are therefore a necessity. Mild cognitive impairment (MCI - defined as a level of cognitive impairment which although noticeable, does not impact sufficiently on an individual's life to be diagnosed as dementia) is seen a stepping stone in the development of dementia, with large numbers of people diagnosed going on to develop dementia over the coming years. One of the main symptoms of dementia and MCI is the detrimental effect that it has on cognitive processes (for example memory, planning, perception and orientation). Within an elderly age group, research suggests that increasing physical activity can have beneficial effects on cognitive processes in later life and this may also be the case in individuals with MCI. This can also be protective as people who are more physically active in their younger years are at less risk of developing dementia as they get older. Unfortunately, many of the studies carried out so far in groups with MCI have not been performed to a high methodological standard, often with mixed groups of dementia participants with different diagnoses of dementia (it is likely that different types of dementia will respond differently to physical activity, just as they do with medications prescribed), in different care settings and without comparable cognitive assessment tools. This means that there is no current clinical advice for individuals with MCI, their caregivers and healthcare professionals as to what sort of physical activity may be beneficial to them as an alternative to current treatments. We propose to develop a behaviour change program which promotes the use of physical activity to maintain cognitive function and prevent cognitive decline in older adults at risk of dementia (those with MCI). This will aim to change the behaviour of both the individual with MCI and the healthcare professionals responsible for their care with the ultimate aim that physical activity can be offered as a healthcare 'prescription' to individuals.

痴呆症目前是一个主要的医疗保健问题。随着人口老龄化，患有痴呆症的人数每年都在增加。这需要付出巨大的人力和财力代价。目前，没有治愈痴呆症的方法，但药物可以帮助延缓疾病的进展，尽管这有不同程度的成功-因此，其他治疗选择，使患者更直接地参与自己的护理是必要的。轻度认知障碍（MCI -定义为认知障碍的水平，虽然明显，但不会对个体的生活产生足够的影响以诊断为痴呆症）被视为痴呆症发展的垫脚石，大量被诊断为痴呆症的人在未来几年内继续发展。痴呆症和MCI的主要症状之一是它对认知过程（例如记忆，规划，感知和定向）的有害影响。在老年人中，研究表明，增加体力活动可以对晚年的认知过程产生有益的影响，这也可能是MCI患者的情况。这也可以起到保护作用，因为年轻时身体活动较多的人随着年龄的增长患痴呆症的风险较小。不幸的是，到目前为止，在MCI患者中进行的许多研究都没有达到很高的方法标准，通常是在不同的护理环境中，在没有可比的认知评估工具的情况下，对不同诊断的痴呆症参与者进行混合组（不同类型的痴呆症可能对身体活动的反应不同，就像他们对处方药物的反应一样）。这意味着目前没有针对MCI患者，他们的护理人员和医疗保健专业人员的临床建议，以确定哪种体力活动可能对他们有益，作为当前治疗的替代方案。我们建议制定一项行为改变计划，促进使用体力活动来维持认知功能，并预防有痴呆风险的老年人（MCI患者）的认知能力下降。这将旨在改变MCI患者和负责其护理的医疗保健专业人员的行为，最终目标是将体育活动作为医疗保健“处方”提供给个人。

项目成果

Muscle Sympathetic Nerve Activity Is Associated with Liver Insulin Sensitivity in Obese Non-Diabetic Men.

肥胖非糖尿病男性的肌肉交感神经活动与肝脏胰岛素敏感性相关。

• DOI: 10.3389/fphys.2017.00101
• 发表时间: 2017
• 期刊: Frontiers in physiology
• 影响因子: 4
• 作者: Chen DL;Brown R;Liess C;Poljak A;Xu A;Zhang J;Trenell M;Jenkins A;Chisholm D;Samocha-Bonet D;Macefield VG;Greenfield JR
• 通讯作者: Greenfield JR

The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants.

• DOI: 10.1371/journal.pone.0187982
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Cassidy S;Trenell MI;Anderson KN
• 通讯作者: Anderson KN

High-intensity interval training: a review of its impact on glucose control and cardiometabolic health.

• DOI: 10.1007/s00125-016-4106-1
• 发表时间: 2017-01
• 期刊: Diabetologia
• 影响因子: 8.2
• 作者: Cassidy S;Thoma C;Houghton D;Trenell MI
• 通讯作者: Trenell MI

Low physical activity, high television viewing and poor sleep duration cluster in overweight and obese adults; a cross-sectional study of 398,984 participants from the UK Biobank.

• DOI: 10.1186/s12966-017-0514-y
• 发表时间: 2017-04-28
• 期刊: The international journal of behavioral nutrition and physical activity
• 作者: Cassidy S;Chau JY;Catt M;Bauman A;Trenell MI
• 通讯作者: Trenell MI

Systematic development of a theory-informed multifaceted behavioural intervention to increase physical activity of adults with type 2 diabetes in routine primary care: Movement as Medicine for Type 2 Diabetes.

• DOI: 10.1186/s13012-016-0459-6
• 发表时间: 2016-07-19
• 期刊: Implementation science : IS
• 作者: Avery L;Charman SJ;Taylor L;Flynn D;Mosely K;Speight J;Lievesley M;Taylor R;Sniehotta FF;Trenell MI
• 通讯作者: Trenell MI