SICKLE CELL ANEMIA AND OTHER HEMOGLOBINOPATHIES

镰状细胞性贫血和其他血红蛋白病

• 批准号: 3097801
• 负责人: Ronald L Nagel
• 金额: $ 146.96万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-06-01 至 1992-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3097801
• 关键词: hemoglobin Ss; hemoglobinopathy; molecular pathology; sickle cell anemia; sickling inhibitor

The present project intends to advance the understanding of the molecular basis of the polymerization of Hb S. We intend to investigate the pregelling events, the role of non-Hb S molecules, and the supramolecular structure of the polymer. We intend to pursue the kinetics of sickling, the ligand kinetics of Hb S containing red cells and the basis of the changes in the oxygen equilibrium curve in these cells. We will continue the development of nitrogen mustards and alkylureas as antisickling agents. We will also inquire into the basis of the stimulation of the synthesis of Hb F in some pathological states, with the hope of understanding its operative control.

本项目旨在促进对分子基础的理解

项目成果

Thrombospondin mediates the cytoadherence of Plasmodium falciparum-infected red cells to vascular endothelium in shear flow conditions.

在剪切流条件下，血小板反应蛋白介导恶性疟原虫感染的红细胞与血管内皮的细胞粘附。

• 发表时间: 1988
• 期刊: Blood
• 影响因子: 20.3
• 作者: Rock,EP;RothJr,EF;Rojas-Corona,RR;Sherwood,JA;Nagel,RL;Howard,RJ;Kaul,DK
• 通讯作者: Kaul,DK

Ligand state of intraerythrocytic circulating HbC crystals in homozygote CC patients.

纯合子 CC 患者红细胞内循环 HbC 晶体的配体状态。

• 发表时间: 1985
• 期刊: Blood
• 影响因子: 20.3
• 作者: Hirsch,RE;Raventos-Suarez,C;Olson,JA;Nagel,RL
• 通讯作者: Nagel,RL

Applications of integrated cell models: novel predictions on the behaviour of red cells and reticulocytes.

集成细胞模型的应用：对红细胞和网织红细胞行为的新预测。

• 发表时间: 1990
• 期刊: Biomedica biochimica acta
• 作者: Lew,VL;Freeman,CJ;Ortiz,OE;Bookchin,RM
• 通讯作者: Bookchin,RM

Lawsone (2-OH-1,4-naphthoquinone) derived form the henna plant increases the oxygen affinity of sickle cell blood.

从指甲花植物中提取的 Lawsone（2-OH-1,4-萘醌）可增加镰状细胞血的氧亲和力。

• DOI: 10.1016/0006-291x(82)91534-0
• 发表时间: 1982
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Chang,H;Suzuka,SE
• 通讯作者: Suzuka,SE

Erythrocyte sedimentation rate during steady state and painful crisis in sickle cell anemia.

镰状细胞性贫血稳态期间的红细胞沉降率和痛苦危机。

• DOI: 10.1016/0002-9343(86)90349-9
• 发表时间: 1986
• 期刊: The American journal of medicine
• 作者: Lawrence,C;Fabry,ME
• 通讯作者: Fabry,ME