In vivo imaging of protective and malignant B cell function

保护性和恶性 B 细胞功能的体内成像

• 批准号: nhmrc : GNT1086977
• 负责人: A/Pr Edwin Hawkins
• 金额: $ 41.18万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vivo-imaging-protective-cell-function/1345685
• 关键词: vivo; imaging; protective; malignant; cell

B cells are responsible for producing antibody that protects us from infection. Disruption of healthy B cell function can lead to a myriad of diseases including immunodeficiency, autoimmunity and blood cancers such as leukaemia. The aim of my work is to use powerful microscopy to visualise how mutated B cells interact with their surrounding environment in real-time. These studies will allow the development of new treatments for cancer and immune conditions that target these interactions.

B细胞负责产生抗体，保护我们免受感染。破坏健康的B细胞功能会导致多种疾病，包括免疫缺陷、自身免疫和血癌，如白血病。我的工作目的是使用强大的显微镜来实时观察突变的B细胞如何与周围环境相互作用。这些研究将有助于开发针对这些相互作用的癌症和免疫疾病的新疗法。