The mezzanine T cell response: intervening at the coal face

夹层 T 细胞反应：在采煤工作面进行干预

• 批准号: nhmrc : GNT1143976
• 负责人: A/Pr Edwin Hawkins
• 金额: $ 76.56万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mezzanine-t-cell-coal-face/1348567
• 关键词: mezzanine; cell; response; intervening; coal

In an initial immune response, specialised cells in lymph nodes tell T cells to multiply; the stimulated T cells depart and enter target tissue (e.g. lung in the case of flu). We describe a new response whereby the target tissue itself can tell T cells to multiply further. This response in target tissues reveals a new way of altering immune responses. This is especially important as in many diseases, the primary lymph node response has already occurred, so cannot be therapeutically intervened.

在最初的免疫反应中，淋巴结中的特化细胞告诉T细胞增殖;受刺激的T细胞离开并进入靶组织（例如流感病例中的肺）。我们描述了一种新的反应，即靶组织本身可以告诉T细胞进一步繁殖。靶组织中的这种反应揭示了改变免疫反应的新方法。这一点尤其重要，因为在许多疾病中，原发性淋巴结反应已经发生，因此无法进行治疗干预。