Long-term in vivo imaging of bone marrow microenvironments in Multiple Myeloma.

多发性骨髓瘤骨髓微环境的长期体内成像。

• 批准号: nhmrc : GNT1145442
• 负责人: A/Pr Edwin Hawkins
• 金额: $ 68.84万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/long-term-vivo-multiple-myeloma/1348693
• 关键词: Long; term; vivo; imaging; bone

White blood cells are soldiers of the immune system. When the machinery that controls growth and death of these cells is disrupted, these cells can undergo massive expansion. This leads to the development of blood cancers such as multiple myeloma (MM). In MM, malignant cells infiltrate bones preventing production of blood and damaging the bone structure leading to fractures. Using cutting edge microcopy we will watch how MM cells grow and damage bone tissue to develop new therapeutic approaches.

白色血细胞是免疫系统的战士。当控制这些细胞生长和死亡的机制被破坏时，这些细胞可以进行大规模的扩增。这导致血癌的发展，如多发性骨髓瘤（MM）。在MM中，恶性细胞浸润骨骼，阻止血液产生并破坏骨骼结构，导致骨折。使用最先进的显微镜，我们将观察MM细胞如何生长和破坏骨组织，以开发新的治疗方法。