UPGRADE OF A 4 7T/40CM GE CSI INSTRUMENT

高磁场强度对于优化信号至关重要， 噪声和光谱分辨率。 为此，4.7T/40 cm孔径GE 这台仪器是三年前购买的，用于基础研究 在不同的动物模型上。 然而，从那时起，NMR技术 技术也有了根本性的进步。 本文书是 过时，并限制了研究的范围和质量， 被执行。 几种技术，特别是空间定位 光谱学，对于本系统是不可行的。 因此，本提案要求对该文书进行升级， 保持核磁共振技术的前沿。 两大升级是 所请求第一种是两组不同的屏蔽梯度， 直径。 这将大大提高我们在空间上的表现能力 本地化光谱，核磁共振显微镜和高速成像大 和小动物模型。 第二次升级是换一台新电脑 基于SUN计算机的控制台。 目前的制度已经过时， 在脉冲序列编程、图形方面限制非常严格 处方、真实的时间参数优化、数据处理，以及 数据存储 这些改进对于继续发展 空间定位光谱和成像的各种研究， 肿瘤科、心脏科、放射科和神经科。

High magnetic field strengths are essential for optimized signal to noise and spectral resolution in NMR. To this end, a 4.7T/40cm bore GE instrument was purchased three years ago and is used for basic research on a variety of animal models. Since that time, however, NMR techniques and technology have radically improved. The present instrument is outdated, and restricts the scope and quality of the research that can be performed. Several techniques, especially spatially localized spectroscopy, are not feasible with the present system. Consequently this proposal requests an upgrade of this instrument to keep it at the cutting edge of NMR technology. Two major upgrades are requested. The first is for two sets of shielded gradients of differing diameters. This will greatly improve our ability to perform spatially localized spectroscopy, NMR microscopy and high speed imaging on large and small animal models. The second upgrade is for a new computer console based on a SUN computer. The present system is outdated and very restrictive with regards to pulse sequence programming, graphic prescription, real time parameter optimization, data processing, and data storage. These improvements are essential for the continued development of spatially localized spectroscopy and imaging for a variety of studies in oncology, cardiology, radiology and neurology at JHMI.