Defining the role of the major subsets of renal mononuclear phogocytes

定义肾单核吞噬细胞主要亚群的作用

• 批准号: nhmrc : 1061848
• 负责人: Dr Yiping Wang
• 金额: $ 40.96万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-major-mononuclear-phogocytes/454937
• 关键词: Defining; role; major; subsets; renal

Chronic Kidney Disease (CKD) is a major cause of death and morbidity in Australia, and currently therapeutic options are limited. Renal mononuclear phagocytes (rMP) are important immune cells which play a central role in health and disease of the kidney. However, rMP are a heterogenous group of cells with a poorly defined role in the development and progression of CKD. We will define the role of major subsets of rMP in CKD, and explore their potential for treating CKD.

慢性肾脏疾病（CKD）是澳大利亚死亡和发病的主要原因，目前治疗选择有限。肾单核吞噬细胞（rMP）是一种重要的免疫细胞，在肾脏的健康和疾病中起着核心作用。然而，rMP是一群异质性细胞，在CKD的发生和进展中作用不明确。我们将定义rMP主要亚群在CKD中的作用，并探讨其治疗CKD的潜力。