Targeting Tregs Using Chimeric Antigen Receptors (CARs) for the Treatment of Autoimmune Renal Disease

慢性肾脏疾病是澳大利亚的主要死亡原因之一。能够针对自身免疫性肾脏疾病的调节性T细胞(Tregs)的治疗成功将具有重大的临床意义。在这项拟议的研究中，我们将使用嵌合抗原受体(CARS)T细胞，将它们重定向到疾病器官，保护肾脏免受损伤。这些CAR T细胞将识别肾脏抗原，并以免疫细胞和抗体为靶点，以限制肾脏损害。

Chronic Kidney Disease is one of the major causes of death in Australia. Therapeutic success with regulatory T cells (Tregs) capable of targeting autoimmune kidney disease would have major clinical implications. In the proposed study, we will use Chimeric Antigen Receptors (CARs) T cells by redirecting them to diseased organs, protect against kidney injury. These CAR T cells will recognise renal antigens and target immune cells and antibodies to limit kidney damage.