Gamma-Delta Tregs, CD8 Tregs and selected natural Tregs to treat renal injury

慢性肾脏疾病（CKD）的进展是由于肾脏的持续损害。我们已经确定了三种类型的白细胞可以减少CKD的肾脏损害。第一种是一组独特的γ - δ T细胞，它们在肾脏中扩张，保护肾脏免受伤害。第二种是一组有限的CD8 T细胞，可以防止肾脏损伤。第三种是靶向的自然调节性T细胞。这些研究将这三个亚群中的每一个都发展为CKD的潜在细胞疗法。

Chronic kidney disease (CKD) progresses due to ongoing damage to the kidney. We have identified three types of white cells that can reduce kidney damage in CKD. The first is a unique set of gamma-delta T cells that expand in the kidney and protect against injury. The second is a restricted set of CD8 T cell that can protect against kidney injury. The third are targeted natural regulatory T cells. These studies develop each of these three subsets as potential cellular therapies in CKD.