Gamma-Delta Tregs, CD8 Tregs and selected natural Tregs to treat renal injury

Gamma-Delta Tregs、CD8 Tregs 和精选的天然 Tregs 用于治疗肾损伤

• 批准号: nhmrc : 632519
• 负责人: Dr Yiping Wang
• 金额: $ 40.35万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gamma-delta-tregs-renal-injury/94785
• 关键词: Gamma; Delta; Tregs; CD8; selected

Chronic kidney disease (CKD) progresses due to ongoing damage to the kidney. We have identified three types of white cells that can reduce kidney damage in CKD. The first is a unique set of gamma-delta T cells that expand in the kidney and protect against injury. The second is a restricted set of CD8 T cell that can protect against kidney injury. The third are targeted natural regulatory T cells. These studies develop each of these three subsets as potential cellular therapies in CKD.

慢性肾脏病（CKD）的进展是由于对肾脏的持续损害。我们已经确定了三种类型的白色细胞，可以减少肾脏损害的慢性肾病。第一种是一组独特的γ-δ T细胞，它们在肾脏中扩增并保护免受损伤。第二种是一组限制性的CD 8 T细胞，可以防止肾损伤。第三种是靶向天然调节性T细胞。这些研究将这三个亚组中的每一个都开发为CKD的潜在细胞疗法。