Redefining the role of macrophages in atherosclerosis: macrophage subset role in plaque stability

重新定义巨噬细胞在动脉粥样硬化中的作用：巨噬细胞亚群在斑块稳定性中的作用

• 批准号: nhmrc : 1006139
• 负责人: Dr Yiping Wang
• 金额: $ 33.95万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/redefining-role-macrophages-plaque-stability/109149
• 关键词: Redefining; role; macrophages; atherosclerosis; macrophage

Vascular disease is a major cause of death and disability through events such as heart attack and stroke. A blood cell, called a macrophage, plays a major detrimental role. However, we have identified the presence of an alternate form of this cell in vascular disease that we propose may play an opposing, beneficial role. We will thus re-define the role of the macrophage in vascular disease and predict that we will be able to demonstrate an alternate healing role. This will provide a new therapeutic approach for treatment of atherosclerosis.

血管疾病是心脏病发作和中风等事件导致死亡和残疾的主要原因。称为巨噬细胞的血细胞起着主要的有害作用。然而，我们已经确定在血管疾病中存在这种细胞的另一种形式，我们认为它可能发挥相反的、有益的作用。因此，我们将重新定义巨噬细胞在血管疾病中的作用，并预测我们将能够证明其替代的治疗作用。这将为动脉粥样硬化的治疗提供新的治疗途径。