DNA vaccination using chemokine and costimulatory pathways as a treatment for chronic kidney disease

使用趋化因子和共刺激途径的 DNA 疫苗接种治疗慢性肾病

• 批准号: nhmrc : 571343
• 负责人: Dr Yiping Wang
• 金额: $ 30.03万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dna-vaccination-using-kidney-disease/99219
• 关键词: DNA; vaccination; using; chemokine; costimulatory

Chronic kidney disease (CKD) is a great burden on Australia. Treatments are mostly ineffective. Our DNA vaccination against mediators of inflammation can protect against CKD. On the basis of ongoing studies we have identified 5 candidate molecules involved in recruitment and activation of inflammatory cells. We outline studies to generate DNA vaccines to these molecules, enhance their efficacy, and test them in models that represent the 3 most important causes of human CKD.

慢性肾脏病（CKD）是澳大利亚的一个沉重负担。治疗大多无效。我们针对炎症介质的DNA疫苗可以预防CKD。在正在进行的研究的基础上，我们已经确定了5个参与炎症细胞募集和激活的候选分子。我们概述了针对这些分子产生DNA疫苗的研究，增强其功效，并在代表人类CKD 3个最重要原因的模型中对其进行测试。